{Stus-List} Bonomine

Walt Dickie waltd at crresearch.com
Fri Jun 12 11:05:13 EDT 2009

Bonomine seems to be the Canadian brand name of a prescription form of meclizine HCl given in a 25 mg. Dose (http://www.rxmed.com/b.main/b2.pharmaceutical/b2.1.monographs/CPS-%20Monographs/CPS-%20(General%20Monographs-%20B)/BONAMINE.html)  

Meclizine is available under several brand names, in both prescription and non-prescription forms.  Drugs.com lists the following: 

In the U.S.-

    * Antivert 3
    * Antivert/25 3
    * Antivert/50 3
    * Bonine 3
    * Dramamine II 3
    * Marezine 2
    * Meclicot 3
    * Medivert 3

In Canada-

    * Bonamine 3
    * Marzine 2 

I've used over the counter Dramamine II for years.  Not sure about its availability in Canada, but it's in every US drugstore where I've ever looked for it.  Probably available online, too.

-----Original Message-----
From: cnc-list-bounces at cnc-list.com [mailto:cnc-list-bounces at cnc-list.com] On Behalf Of Hoyt, Mike
Sent: Friday, June 12, 2009 9:34 AM
To: cnc-list at cnc-list.com
Subject: Re: {Stus-List} Bonomine

Thanks Bill

We liked Bonomine because you could take it the morning of a day trip and it would be efefctive.  The Transderm patch had to be applied well in advance and was overkill for a 6 hour trip. Gravol - who wants to sleep when they are out to enjoy a sail?

I was just speaking to a pharmcist and the only variations of the meclizine family availavle in Canada are the patch and gravol.  Bummer.

However she did state that "Ginger Gravol" i non drowsy since it s main ingredient is Ginger and has the rest at a lesser dose than gravol.  It is available locally and seems worth a try

She also mentioned that Bonomine is not discontinued to her knowledge just "short" - which means the pharmacies cannot get any at this time


-----Original Message-----
From: cnc-list-bounces at cnc-list.com [mailto:cnc-list-bounces at cnc-list.com] On Behalf Of Bill Coleman
Sent: June 12, 2009 11:16 AM
To: cnc-list at cnc-list.com
Subject: Re: {Stus-List} Bonomine

Mike - When it gets very lumpy and I leave the helm for a period, I quite often become stricken.

The Transderm Scop saved me and my daughters a few times. I like it, and other than cotton mouth, no side effects other than It seemed to allow me to drink more without ill effects. Make sure any females are NOT pregnant when taking this.
You just reminded me, and I just entered a request for Scopace, the tablet form of the patch - I have 29 pages on the subject, very informative, but too big to post here - I will email it to you. The last page has the most interesting suggestion, 

<<Seasickness Comments (from Practical Sailor Mailport, Feb 09) I am an offshore sailor, susceptible to seasickness, and a practicing anesthesiologist. It is with this expertise that I offer the following thoughts on your excellent recent article on "Cures Seasickness" (Practical Sailor, January 2009).
I have been using Transderm Scop since its introduction, both on the boat and for treating post operative nausea. In fact, we had some samples from a drug rep that we tried on a Marion Bermuda Race in the early 1980s before the drug was available to the public. I have seen all of the side effects you mention in your article.
However, if one limits the time that the patch is worn to 24 to 36 hours maximum, the side effects will be minimal in most people. I was pleased to learn about Scopace in your article. I believe it is a better alternative to the patch because of the dosing flexibility and more rapid onset of effectiveness.
I am surprised that you did not mention Dexedrine, dextroamphetamine, in your article. The gold standard for relief of motion sickness is a combination of oral Scopolamine (0.4 mg) taken with Dexedrine (2.5-5 mg).
This combination works very quickly and is the only regimen that will relieve symptoms of seasickness even when they are well established.
However, the dexedrine requires a physician's prescription, and many physicians will not be familiar with the use of dexedrine for motion sickness. You can find extensive references to share with your physician by Googling "Dexedrine and Scopolamine for Motion Sickness."
Dexedrine is an amphetamine and as such is a controlled drug, so you need to be sure you have a valid prescription to keep it on board. This combination was developed by NASA to treat motion sickness in astronauts. Ephedrine is a more benign stimulant without the negative connotations of an amphetamine that can be used as an alternative to dexedrine in a dose of 12.5-25mg by mouth, but again not without your physician's advice.
The definitive expert on motion sickness is Dr. Charles Oman, director of the Manned Vehicle Lab at MIT, who is also a sailor. I have heard him speak at Safety at Sea Seminars and seen articles he has written in sailing publications.
Dr. Richard Lilly,
South Glastonbury, Conn.>>

I am trying to cop this combination now - ;^)

Bill Coleman
C&C 39

We have been using Bonomine for the past seven years.  It is great because it is non drowsy and seems to have little side effects as well as cheap and good for 24 hrs.

This year I have been told it is no longer being manufactured.

Anybody know anything on this?  Is there some suitable replacement?

The pharmacist suggest the patch (takes a long tome to take effect and lasts
longer) or Gravol(drowsy).  Neither of which I like.


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